Why we can't develop Coronavirus Vaccine?

Yes. It's not a clickbait. I am sure about this. I am publishing this article After looking over several articles and WHO reports. Why are we not able to develop a vaccine for SARS-CoV-2 i.e., Coronavirus? Let's go deeper.

Coronavirus Vaccine


The Present Conditions

Most vaccines under development worldwide have been modeled on the initial ‘D-strain’ of the virus, which was more prevalent amongst chains proclaimed early in the pandemic. Since then, the virus has evolved to the globally dominant ‘G-strain’, which now accounts for about 85 percent of published SARS-CoV-2 genomes. That's why most of the vaccines under-development are failing.

Well, Coronavirus is not a new thing. It has a really old history.


The History of Coronavirus

The 1920s: An acute respiratory infection of domesticated chickens emerged in North America.

1931: M.C. Hawn in 1931 made the first detailed report which described a new respiratory infection of chickens.

1933: Leland David Bushnell and Carl Alfred Brandly isolated the virus that caused the infection.

1937: Charles D. Hudson and Fred Robert Beaudette cultivated the virus for the first time

The 1940s: Two more animal coronaviruses, JHM that causes brain disease(murine encephalitis) and mouse hepatitis virus (MHV) that causes hepatitis in mice were discovered.

The 1960s: Human Coronaviruses were discovered.

1961: E.C. Kendall, Malcolm Bynoe, and David Tyrrell collected a unique common cold virus designated B814.

1965: Tyrrell and Bynoe successfully cultivated the novel virus.

2003: SARS-CoV, HCoV NL63

2004: HCoV HKU1

2013: MERS-CoV

2019: SARS-CoV-2


Microbiology and the timelines of Coronavirus suggest to us that they are not separate, they are evolving. SARS-CoV-2 is somewhere the descendant of SARS-CoV that is the first Human Coronavirus discovered. But are we able to prevent us from it? The answer is NO.


What Researchers Say?

As I have stated earlier that the virus has evolved to the globally dominant ‘G-strain’, which now accounts for about 85 percent of published SARS-CoV-2 genomes. There had been fears the G-strain, within the main protein on the surface of the virus, would negatively affect vaccines under-development. 

At speed, is only possible through collaboration with allies globally.


Sources

  1. Experimental and in silico evidence suggests vaccines are unlikely to be affected by D614G mutation in SARS-CoV-2 spike protein.
  2. History of Coronavirus
  3. Interactive COVID-19 Timeline


The End Notes

That's all in this article. I hope you liked it. Please share it among your family groups and friends and suggest them to eat healthily, stay fit, and wish them all a happy life journey ahead. Have a good one.

Cheers!

Your Views

Post a comment

0 Comments